Looking for efficiency rather than efficacy in randomized controlled trials in oncology

Looking for efficiency rather than efficacy in randomized controlled trials in oncology.

Blindness in Randomized Controlled Trials

In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...

blindness in randomized controlled trials

in combination with randomization, blinding or masking is an important factor in randomized controlled trials (rcts), particularly in trials that assess therapeutic effects. here an attempt is made to explain blindness and why it is important. in clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...

Efficacy and safety of inhaler steroids in COPD patients: Systematic review and meta-analysis of randomized placebo-controlled trials

Background: Chronic obstructive pulmonary disease (COPD) is a major health dilemma and cause of morbidity and mortality in either industrialized or developing countries and inhaled corticosteroids are widely used worldwide in these patients. In this systematic review, we aimed to analyze the effectiveness of these gents compared to placebo. Methods: Pubmed and Google Scholar literature search ...

Efficacy dilution in randomized placebo-controlled vaginal microbicide trials

BACKGROUND To date different vaginal gel microbicides have been evaluated in phase 2b/3 trials, but none have demonstrated effectiveness for preventing HIV infection. Failure to demonstrate effectiveness however does not necessarily indicate that a product is truly inefficacious, as several sources of efficacy dilution may compromise our ability to identify products that may have been truly eff...